Frailty, distinct from chronological age, reflects physiologic reserve and predicts toxicity, treatment discontinuation, and survival across hematologic malignancies. The authors synthesize contemporary frailty tools and summarize disease-specific evidence in multiple myeloma, acute myeloid leukemia, and aggressive lymphomas. Integrating frailty measures can inform shared decision-making and guide the management of vulnerable populations to enhance therapeutic benefit and optimize quality of life.
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Reed Friend
Levine Cancer Institute
P. Connor Johnson
Daphne Campbell
University of Pennsylvania
Cancer
University of Pennsylvania
Massachusetts General Hospital
The Ohio State University
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Friend et al. (Wed,) studied this question.
synapsesocial.com/papers/69d893896c1944d70ce04777 — DOI: https://doi.org/10.1002/cncr.70375