Abstract BACKGROUND: Ayurveda conceptualizes all matter through Panchamahabhuta - Prithvi, Aap, Teja, Vayu and Akasha , which define both physical structure and functional behavior of substances. OBJECTIVE: To propose an integrative methodology for determining Panchamahabhuta predominance in new or emerging entities using classical Ayurvedic principles alongside modern analytical tools. MATERIALS AND METHODS: The study integrates organoleptic evaluation with physicochemical and spectroscopic analyses including DSC, TGA, GC–MS, XRD and SEM to assess elemental predominance. RESULTS: Conceptual correlations between classical Ayurvedic attributes and modern measurable parameters were identified. Case examples demonstrated that elemental dominance can be systematically aligned with physicochemical characteristics. CONCLUSION: The proposed framework supports the scientific integration of Panchamahabhuta theory into contemporary research and may aid pharmacognostic classification, formulation design and integrative material science applications.
Abhimanyu Kumar (Wed,) studied this question.