What question did this study set out to answer?

The aim is to investigate the role of CD8+ regulatory T cells in modulating eosinophilic infiltration in an allergic asthma model.

April 10, 2026Clinical & Experimental Allergy0 citations

Novel CD8 + Regulatory T Cells Attenuate Eosinophilic Infiltration in a Murine Allergic Asthma Model

View Full Paper

JFJia‐Ning FanNational Taiwan University TCT.-T. ChenNational Taiwan University BCBor‐Luen ChiangNational Taiwan University

Key Points

The aim is to investigate the role of CD8+ regulatory T cells in modulating eosinophilic infiltration in an allergic asthma model.
Utilized a murine model induced by OVA for asthma.
Administered CD8+ T regulatory cells derived from B cells.
Measured levels of Th2 cytokines (IL-4, IL-5, IL-13) and eosinophilic infiltration in BALF.
CD8+ Tregs significantly suppressed Th2 cytokine proliferation.
Eosinophilic infiltration in bronchoalveolar lavage fluid (BALF) was downregulated by CD8+ Tregs.

Abstract

Summary CD8 + Treg‐of‐B cells suppressed Th2 proliferation and the levels of IL‐4, IL‐5, and IL‐13. In an OVA‐induced asthma model, CD8 + Treg‐of‐B cells downregulated eosinophilic infiltration in BALF.

KI fragen

Bookmark

View Full Paper

Cite This Study

Fan et al. (Wed,) studied this question.

synapsesocial.com/papers/69d895be6c1944d70ce06cb2 https://doi.org/https://doi.org/10.1111/cea.70301

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

KI fragen

Bookmark

View Full Paper