What question did this study set out to answer?

The study aims to identify interactions disrupted by artesunate targeting POLH in human kidney cells.

April 10, 2026

Chemical proteomics-based identification of artesunate as a POLH-PHB1 interaction disruptor

Key Points

The study aims to identify interactions disrupted by artesunate targeting POLH in human kidney cells.
Conducted a chemical proteomics approach to profile POLH interactome changes.
Utilized HEK293T human embryonic kidney cells for experimentation.
Analyzed the inhibitory effects of artesunate on protein interactions.
Identified artesunate as a disruptor of POLH-PHB1 interactions.
Demonstrated significant alterations in the POLH interactome upon treatment with artesunate.

Abstract

A chemical proteomics approach was employed to quantitatively profile the changes in the POLH interactome upon artesunate treatment in HEK293T human embryonic kidney cells. The results demonstrated the inhibitory effect...

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Authors

Donghui Ma

Hunan University

Jiawen Li

Hunan University

qiao He

Hunan University

Journals

Chemical Communications

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Chemical proteomics-based identification of artesunate as a POLH-PHB1 interaction disruptor

Key Points

Abstract

Citation Network

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Authors

Journals

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References and Citations

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