Antidepressants and risk of pneumonia in older adults: a nationwide self-controlled case series

Key Points

• The aim was to investigate the association between antidepressant use and pneumonia hospitalisation in older adults.
• Utilized a nationwide self-controlled case series design
• Focused on older adults with and without neurologic conditions
• Analyzed the risk associated with antidepressants and high anticholinergic/sedative burden
• Antidepressant use linked to higher pneumonia hospitalisation rates
• Increased risk particularly noted in those with neurologic conditions
• Need for personalized prescriptions and regular medication reviews highlighted

Structured PICO

Abstract