Does QT dispersion assessment provide clinical utility as a marker of arrhythmogenicity in survivors of myocardial infarction?
QT dispersion assessment has methodological inconsistencies, and more objective techniques like spectral analysis may be needed for reliable noninvasive assessment of ventricular repolarization.
QT dispersion as a measure of interlead variations of QT interval duration in the surface 12-lead ECG is believed to reflect regional differences in repolarization heterogeneity and thus, may provide an indirect marker of arrhythmogenicity. Methodology for determining QT dispersion and reproducibility of this parameter vary significantly between studies and, together with some other unresolved problems with QT dispersion assessment, often lead to contradictory suggestions about potential clinical utility of this parameter. The results of our own study in 213 survivors of myocardial infarction, together with a comprehensive review of the literature, suggest that most of these inconsistencies reflect incomplete understanding of electrocardiographic correlates of both normal and abnormal ventricular repolarization. The application of more objective techniques, such as spectral analysis or combined assessment of different parameters (e.g., area beneath the T wave and its symmetricity) may add a new dimension to the noninvasive assessment of ventricular repolarization.
Kautzner et al. (Wed,) studied this question.