Proteomic analysis of PAH lung tissues reveals altered protein expression, notably increased chloride intracellular channel 4, which may contribute to disorganized angiogenesis.
Label-free proteomics identified differences in the expression of several proteins in the pulmonary arterial hypertension lung, many of which are relevant to the disease process. Increased expression of chloride intracellular channel 4 may be pertinent to the disorganized angiogenesis of plexiform lesions.
Abdul‐Salam et al. (Tue,) studied this question.