September 18, 2025Open Access

The effects of consumption of interesterified fats rich in palmitic acid compared with stearic acid on intermediary markers of cardiometabolic disease risk: a randomized controlled trial in healthy adults

WHWendy L. HallKing's College London EWEleanor WoodDuke University PJPeter J. JorisPreventive Cardiology

Structured PICO

Does consumption of interesterified fats rich in palmitic acid improve total:HDL cholesterol ratio or other CMD risk markers in healthy adults?

Population

Healthy adults

Intervention

Palmitic acid-rich interesterified (IE) fats consumed at 10% energy for a 6-week period

Comparator

Stearic acid-rich fats

Outcome

Total:HDL cholesterol ratio or other cardiometabolic disease (CMD) risk markerssurrogate

Short-term consumption of palmitic acid-rich interesterified fats does not worsen cardiometabolic risk markers compared to stearic acid-rich fats in healthy adults.

Abstract

Commercially relevant palmitic acid-rich IE fats consumed at 10% energy for a 6-wk period do not adversely affect total:HDL cholesterol ratio or other CMD risk markers compared with stearic acid-rich fats. Long-term effects could not be determined from this trial. This trial was registered at clinicaltrials.gov as NCT04418102.

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