Preferential Tumor Vascular Damage Is the Common Antitumor Mechanism of High-Dose Hypofractionated Radiation Therapy: SABR, Spatially Fractionated Radiation Therapy, and FLASH Radiation Therapy

Remarkable technological advances in recent years led to the development of new radiation therapy methods, such as SABR, SFRT (spatially fractionated radiation therapy), and FLASH-RT (FLASH radiation therapy). The common features of these novel radiation therapy techniques are that they deliver high-dose radiation per fraction to tumors and effectively destroy tumor tissues, and yet they significantly spare adjacent normal tissues. Divergent mechanisms specific to each of these techniques have been proposed to account for their ability to spare normal tissues.