January 1, 2014

Endoplasmic reticulumtargeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(iv) vitamin-B6 complex in visible light

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Abstract

An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. VO(HL)(acdppz)Cl, having (acridinyl)dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400-700 nm) in HeLa and MCF-7 cancer cells (IC50 40 μM).

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Banerjee et al. (Wed,) studied this question.

synapsesocial.com/papers/69d8f75f17a1cc0598d1903e https://doi.org/https://doi.org/10.1039/c4cc02093f

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