January 23, 2014Open Access

Interleukin 1 Receptor 1 and Interleukin 1β Regulate Megakaryocyte Maturation, Platelet Activation, and Transcript Profile During Inflammation in Mice and Humans

LBLea M. BeaulieuUniversity of North Carolina at Chapel Hill ELElaine Y. LinNYU Langone Health EMEric MickBoston University

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Abstract

In summary, IL1R1- and IL1β-related transcripts are elevated in the setting of obesity. IL1R1/IL1β augment both megakaryocyte and platelet functions, thereby promoting a prothrombotic environment during infection and obesity; potentially contributing to the development of atherothrombotic disease.

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Beaulieu et al. (Thu,) studied this question.

synapsesocial.com/papers/69d90158537c710c9cae2c78 https://doi.org/https://doi.org/10.1161/atvbaha.113.302700

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