September 28, 2011Open Access

NLRP3 inflammasome–mediated neutrophil recruitment and hypernociception depend on leukotriene B4in a murine model of gout

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Abstract

These results reveal the role of the NLRP3 inflammasome in mediating MSU crystal-induced inflammation and dysfunction of the joints, and highlight a previously unrecognized role of LTB(4) in driving NLRP3 inflammasome activation in response to MSU crystals, both in vitro and in vivo.

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Amaral et al. (Wed,) studied this question.

synapsesocial.com/papers/69d91cab8988aeabbe684279 https://doi.org/https://doi.org/10.1002/art.33355

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