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Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on the NP surface were modified with maleimide functionality for specific covalent immobilization of biopolymers and bioactive small molecules. The sequence-independent immobilization of antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit specific recognition for floating tumor cells or target the membrane of adherent breast cancer cells.
Yoon et al. (Thu,) studied this question.