March 29, 2011Open Access

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

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Abstract

The results confirm that in some communities adult female worms were non-responsive or resistant to the anti-fecundity effects of multiple treatments with IVM. A scheme of the varied responses of the adult female worm to multiple treatments is proposed.

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Osei‐Atweneboana et al. (Tue,) studied this question.

synapsesocial.com/papers/69d93ce49402b8412aa3c9eb https://doi.org/https://doi.org/10.1371/journal.pntd.0000998

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Viability and fertility of adult Onchocerca volvulus after 6 years of treatment with ivermectin1996 · 48 citations
2Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana2004 · 149 citations
3Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study2007 · 383 citations
4Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment2007 · 111 citations
5High-level ivermectin resistance in a field isolate of Haemonchus contortus associated with a low level of resistance in the larval stage: implications for resistance detection2002 · 23 citations

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