Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-β signaling and EMT, thus stimulating breast cancer cell invasion and metastasis.

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Tu et al. (Thu,) studied this question.

synapsesocial.com/papers/69d954e4da3af5b1d0836438 https://doi.org/https://doi.org/10.1186/s13058-017-0904-8

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A rapid in vitro assay for quantitating the invasive potential of tumor cells.1987 · 1,793 citations
2Cancer statistics, 20162016 · 16,157 citations
3Glycosylation in Cellular Mechanisms of Health and Disease2006 · 2,819 citations
4Epithelial-Mesenchymal Transitions in Development and Disease2009 · 9,965 citations
5Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity2002 · 1,823 citations