August 16, 2021Open Access
Oral Anticoagulants for Nonvalvular Atrial Fibrillation in Patients With High Risk of Gastrointestinal Bleeding
Structured PICO
Do NOACs reduce stroke and/or systemic embolism compared to warfarin in patients with nonvalvular atrial fibrillation and high risk of gastrointestinal bleeding?
P
Population
Patients with nonvalvular atrial fibrillation (NVAF) and high risk of gastrointestinal (GI) bleeding
I
Intervention
Non-vitamin K antagonist oral anticoagulants (NOACs)
C
Comparator
Warfarin
O
Outcome
Stroke and/or systemic embolism (SE)hard clinical
In patients with NVAF and high GI bleed risk, NOACs are associated with lower rates of stroke/systemic embolism compared to warfarin, though major bleeding risks vary.
Abstract
In this study of patients with NVAF and high risk of GI bleed, NOACs were associated with lower rates of stroke and/or SE, but NOACs had varying risks of MB compared with warfarin. These results may help inform treatment options in this patient population.