Does combined thyroid and glucocorticoid hormone treatment promote functional T-tubule development in human-induced pluripotent stem cell-derived cardiomyocytes?
Combined thyroid and glucocorticoid hormone treatment promotes functional maturation of hiPSC-CMs, potentially advancing their use in disease modeling and cell-based therapy.
Our results suggest a permissive role of combined thyroid and glucocorticoid hormones during the cardiac differentiation process, which when coupled with further maturation on Matrigel mattress, is sufficient for T-tubule development, enhanced Ca-induced Ca release, and more ventricular-like excitation-contraction coupling. This new hormone maturation method could advance the use of hiPSC-CM for disease modeling and cell-based therapy.
Parikh et al. (Wed,) studied this question.