Esketamine/dexmedetomidine-based opioid-free anesthesia modulates perioperative neuro-inflammatory biomarkers and enhances postoperative cognitive recovery in patients undergoing total laparoscopic hysterectomy

Key Points

• The aim is to evaluate the effects of esketamine/dexmedetomidine-based opioid-free anesthesia on neuro-inflammatory biomarkers and cognitive recovery after surgery.
• Utilized esketamine and dexmedetomidine for opioid-free anesthesia during total laparoscopic hysterectomy.
• Measured perioperative levels of IL-6 and NSE biomarkers.
• Assessed postoperative cognitive dysfunction (POCD) incidence
• Significantly reduced IL-6 and NSE levels in patients receiving the intervention.
• Lower incidence of early postoperative cognitive dysfunction compared to traditional anesthesia.