Do polypharmacy and cumulative anticholinergic burden increase falls risk in older adults?
Polypharmacy and cumulative anticholinergic burden are strong risk factors for falls in older adults, outweighing the effects of age and comorbidities.
Polypharmacy results in cumulative ACB and both are significantly associated with falls risk in older adults. The presence of polypharmacy and each unit rise in ACB score have a stronger effect of increasing falls risk compared to age and comorbidities.
Wong et al. (Wed,) studied this question.