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The non-clinical basic science literature provides evidence for numerous mechanisms in which HA acts on joint structures and function. These actions provide support for the purported clinical benefit of IA-HA in OA of the knee. Future research should not only focus on the pain relief provided by IA-HA treatment, but the disease modification properties that this treatment modality possesses as well.
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BMC Musculoskeletal Disorders
University of California, Los Angeles
McMaster University
Ferring Pharmaceuticals (United States)
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Altman et al. (Mon,) studied this question.