Design, synthesis, antiviral activity and three‐dimensional quantitative structure–activity relationship study of novel 1,4‐pentadien‐3‐one derivatives containing the 1,3,4‐oxadiazole moiety

Some of the title compounds displayed good antiviral activities. 3D-QSAR models revealed that the appropriate compact electron-withdrawing and hydrophobic group at the benzene ring could enhance antiviral activity. These results could provide important structural insights for the design of highly active 1,4-pentadien-3-one derivatives.