August 30, 2018Open Access

Angiotensin‐converting enzyme inhibitor works as a scar formation inhibitor by down‐regulating Smad and TGF‐β‐activated kinase 1 (TAK1) pathways in mice

WTWei‐Qiang TanSir Run Run Shaw Hospital QFQing‐Qing FangSir Run Run Shaw Hospital XSXiao Z. ShenZhejiang University

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Abstract

ACEI showed anti-fibrotic properties in scar formation by mediating downstream peptides to suppress TGF-β1/Smad and TGF-β1/TAK1 pathways. These findings suggest that dual inhibition of Smad and TAK1 signalling by ACEI is a useful strategy for the development of new anti-fibrotic agents.

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Tan et al. (Thu,) studied this question.

synapsesocial.com/papers/69da28bea6045d71bfa3c4e2 https://doi.org/https://doi.org/10.1111/bph.14489

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