June 20, 2016Open Access

Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints

FVFemke de VeldeErasmus MC BWBrenda C. M. de WinterErasmus MC BKBirgit C. P. KochErasmus MC

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Abstract

The amoxicillin absorption rate appears to be saturable. The PTAs of high-dose as well as twice-daily regimens are less favourable than regimens with lower doses and higher frequency.

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Velde et al. (Mon,) studied this question.

synapsesocial.com/papers/69da44650d540cafc5838d90 https://doi.org/https://doi.org/10.1093/jac/dkw226

Also Consider

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1Bioavailability of Ampicillin and Amoxicillin in Fasted and Nonfasted Subjects1977 · 111 citations
2[Studies on the pharmacokinetics of amoxicillin after intravenous, intramuscular and oral administration (author's transl)].1981 · 14 citations
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4Pharmacokinetics Study of Amoxycillin and Clavulanic acid (8:1)-A New Combination in Healthy Chinese Adult Male Volunteers Using the LC–MS/MS Method2012 · 11 citations
5Pharmacokinetics of Amoxicillin: Dose Dependence After Intravenous, Oral, and Intramuscular Administration1977 · 130 citations

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