Does the selective NLRP3-inflammasome inhibitor MCC950 reduce infarct size and preserve cardiac function in a pig model of myocardial infarction?
In a translational pig model of myocardial infarction, the NLRP3-inflammasome inhibitor MCC950 successfully reduced infarct size and preserved cardiac function, indicating potential therapeutic value for acute MI.
NLRP3-inflammasome inhibition reduces infarct size and preserves cardiac function in a randomized, blinded translational large animal MI model. Hence, NLRP3-inflammasome inhibition may have therapeutic potential in acute MI patients.
Hout et al. (Sun,) studied this question.