October 22, 2009Open Access

Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function

MKMaciej KmieciakVirginia Commonwealth University MGMadhu GowdaUniversity of Wisconsin–Madison LGLaura GrahamVirginia Commonwealth University

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Abstract

Expression of Foxp3 does not necessarily convey regulatory function in human CD4+CD25+ T cells. Increased FoxP3 on CD44+ effector and CD44+CD62L+ memory T cells upon stimulation suggest the activation-induced regulation of FoxP3 expression.

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