April 23, 2021Open Access

G-quadruplexes are transcription factor binding hubs in human chromatin

JSJochen SpiegelUniversity of Cambridge SCSergio Martínez CuestaAstraZeneca (Australia)SASantosh AdhikariUniversity of Cambridge

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Abstract

Our results reveal a novel non-canonical mechanism for TF binding whereby G4s operate as common binding hubs for many different TFs to promote increased transcription.

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Spiegel et al. (Fri,) studied this question.

synapsesocial.com/papers/69dac447e6ab964fb0836a92 https://doi.org/https://doi.org/10.1186/s13059-021-02324-z

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