Systemic inflammation and dyslipidemia are associated with retinopathy in type 2 but not in type 1 diabetes

The aim of this study was to investigate risk factors and role of systemic inflammation, dyslipidemia and obesity in development of diabetic retinopathy (DR) in type 1 and type 2 diabetes and determine the differences in risk factors between these two types of diabetes. Eighty-four type 1 and 107 type 2 diabetic patients were included in this cross-sectional study. Diabetes duration, body mass index (BMI) and waist-to-hip ratio (WHR) were assessed. C-reactive protein (CRP), fibrinogen (FIB), glycated hemoglobin (HbA1c), fasting and postprandial blood glucose (fBG, ppBG), HDL and LDL cholesterol and triglycerides (TG) were determined using routine methods. HbA1cmedian was obtained by statistical analysis of the CroDiabNet data and used as a marker of long-term glycemic control. Albumin excretion rate (AER) was measured in a 24-hour urine collection. Ophthalmologic retinal examination included indirect slit-lamp fundoscopy, color fundus photography according to EURODIAB (EUROpe and DIABetes) protocol and optical coherence tomography. DR was positively related to diabetes duration (p 1cmedian (p p = .008) in type 1, and diabetes duration (p 1cmedian (p = .018), AER (p p = .048) and TG (p = .041) in type 2 diabetes. Regression analysis showed that diabetes duration (OR 1.20, p = .005) and HbA1cmedian (OR 6.92, p = .007) were the main predictors of DR in type 1, and diabetes duration (OR 1.17, p p = .024) and TG (OR 2.08, p = .025) in type 2 diabetes. In conclusion, systemic inflammation and dyslipidemia are associated with DR in type 2 but not in type 1 diabetes.