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October 10, 2022Open Access

Magnetic ResonanceImages Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction inAlzheimer Disease

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Abstract

Glymphatic system activity may act as a significant mediator in AD-related cognitive dysfunction even after adjusting for multiple covariates and gray matter volumes. ALPS-index may provide useful disease progression or treatment biomarkers for patients with AD as an indicator of modulation of glymphatic activity. ANN NEUROL 2023;93:164-174.

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Authors

Jung‐Lung Hsu

University of North Carolina at Chapel Hill

Yi‐Chia Wei

Memorial Hospital of South Bend

Cheng‐Hong Toh

Chang Gung University

Journals

Annals of Neurology

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Institutions

National Yang Ming Chiao Tung University

Chang Gung University

Chang Gung Memorial Hospital

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Hsu et al. (Mon,) studied this question.

synapsesocial.com/papers/69db23780d8d6ef495a3d0b8 — DOI: https://doi.org/10.1002/ana.26516

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Unified segmentation· 2005 · 7,521 citations
Glymphatic Dysfunction in Patients With Ischemic Stroke· 2021 · 102 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study· 2014 · 196 citations
“Mini-mental state”· 1975 · 86,742 citations
Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent — a pilot study· 2010 · 127 citations
Unified segmentation· 2005 · 7,521 citations
Glymphatic Dysfunction in Patients With Ischemic Stroke· 2021 · 102 citations

Magnetic ResonanceImages Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction inAlzheimer Disease

Key Points

Abstract

Citation Network

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

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