March 1, 2022Open Access

Cerebrospinal fluid and venous biomarkers of shunt-responsive idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis

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Abstract

This meta-analysis found that lumbar CSF levels of Phosphorylated-Tau and Total-Tau are significantly increased in shunt non-responsive iNPH compared to shunt-responsive iNPH. The other biomarkers, including amyloid-β 1-42, did not significantly differentiate shunt-responsive from shunt-non-responsive iNPH. More studies on the Tau proteins examining sensitivity and specificity at different cut-off levels are needed for a robust analysis of the diagnostic efficiency of the Tau proteins.

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Thavarajasingam et al. (Tue,) studied this question.

synapsesocial.com/papers/69db29ee4a1e15904c8371be https://doi.org/https://doi.org/10.1007/s00701-022-05154-5

Discussion

Journals

Acta Neurochirurgica

Institutions

Imperial College London

University of Oslo

Oslo University Hospital

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