Treatment with exemestane and pazopanib maintained a relatively stable clinical condition without distant metastasis in a 76-year-old female with recurrent radiation-induced breast angiosarcoma.
Case Report (n=1)
No
This case report describes a patient with recurrent radiation-induced angiosarcoma who maintained a stable clinical condition without distant metastasis following surgery and systemic therapy with exemestane and pazopanib.
Radiation-induced sarcomas represent a rare but aggressive complication following breast cancer treatment, often associated with significant biological heterogeneity and limited therapeutic options. Their clinical course is frequently characterized by high recurrence rates and limited responsiveness to conventional therapies. We report a case of a 76-year-old female with a history of left-sided breast cancer treated in 2017, who subsequently developed a high-grade radiation-induced soft tissue sarcoma of the chest wall. The patient underwent multiple surgical resections due to recurrent disease. Systemic treatment included exemestane as endocrine therapy and pazopanib as antiangiogenic targeted therapy, both administered according to a consistent daily schedule. Laboratory findings demonstrated a relatively stable neutrophil-to-lymphocyte ratio of approximately 3.0-3.5 in the context of a persistent inflammatory profile. Despite aggressive tumor biology and multiple comorbidities, the patient maintained a relatively stable clinical condition without evidence of distant metastasis. An additional observation in this case was the consistent daily timing of systemic therapy administration. While not formally evaluated, this pattern may represent a potentially relevant aspect of treatment delivery and could warrant further investigation.
Bivolarski et al. (Thu,) conducted a case report in Radiation-induced angiosarcoma of the breast (n=1). Exemestane and pazopanib was evaluated. Treatment with exemestane and pazopanib maintained a relatively stable clinical condition without distant metastasis in a 76-year-old female with recurrent radiation-induced breast angiosarcoma.