Pyridine-boryl radical mediated synthesis of quinolines via α-amino radical formation and intramolecular alkenyl sulfone trapping

Key Points

• The aim is to explore the synthesis of quinolines through the mediation of pyridine-boryl radicals and α-amino radicals.
• Utilized pyridine-boryl radicals to form α-amino radicals from imines.
• Conducted a 6-endo-trig intramolecular trapping with alkenyl sulfones.
• Performed reactions under mild conditions to evaluate product formation.
• Successfully synthesized quinolines from the reaction of pyridine-boryl radicals.
• Achieved formation of α-amino radicals leading to effective quinoline formation.
• Confirmed the method's efficacy under mild reaction conditions.

Abstract