GADD45B promotes apoptosis in intestinal ischemia/reperfusion through DNA demethylation of MST1/Hippo | Synapse
April 12, 2026Open Access
GADD45B promotes apoptosis in intestinal ischemia/reperfusion through DNA demethylation of MST1/Hippo
Key Points
This research explores the role of GADD45B in inducing cell death during intestinal ischemia/reperfusion injury and its underlying mechanisms.
Examined the regulatory role of GADD45B in intestinal ischemia/reperfusion injury
Analyzed the GADD45B/TET1/MST1 molecular pathway
Evaluated effects of DNA demethylation on MST1 expression
GADD45B significantly induces apoptosis in intestinal injury contexts
Targeting the GADD45B/TET1/MST1 axis shows potential for therapeutic applications
DNA demethylation positively regulates MST1, key in the Hippo pathway
Abstract
GADD45B represents a pivotal regulatory factor in intestinal I/R injury, and targeting the GADD45B/TET1/MST1 axis might serve as a feasible treatment strategy.