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Poly(ether-ester urethane)s (PUs) multiblock co-polymers were synthesized from telechelic hydroxylated poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and poly(ethylene glycol) (PEG) via a melting polymerization (MP) process using 1,6-hexamethylene diisocyanate (HDI) as a non-toxic coupling agent for the first time. The PHBHHx segments and PEG segments in the multiblock co-polymers behaved as a hard, hydrophobic and a soft, hydrophilic part, respectively. Their chemical structures and molecular characteristics were studied by gel-permeation chromatography (GPC), (1)H-NMR and Fourier transform infrared spectroscopy (FT-IR). The PU produced via the MP method showed a higher molecular weight than those resulting from the solvent polymerization (SP) reported previously. Thermal properties showed enhanced thermal stability with semi-crystalline morphology via incorporation of PEG. The segments compositions evaluated from thermogravimetric analysis (TGA) two-step thermal decomposition profiles suggested that MP enhanced the reactivity of PEG compared with the SP process. It was in good agreement with those calculated from (1)H-NMR, as well as the precursor feed ratio, respectively. Water contact angle measurements revealed that surface hydrophilicity of the PUs was enhanced by incorporating the PEG segment into PHBHHx polymer backbone. The mechanical properties assessment of the PUs recorded an improved and adjustable ductility and toughness than pure PHBHHx while preserving the tensile strength. Samples synthesized via MP were resistant to hydrolytic and lipase degradation, yet the multiblock co-polymers incorporating the highest amount of PEG degraded at the highest rate. SEM studies revealed that the surface of the PU films became increasingly porous as the degradation proceeded. Implantation of PU in mouse abdominal cavity indicated that tissue regeneration and tissue compatibility of PU film was better than that of PHBHHx-only film.
Li et al. (Thu,) studied this question.