Pineapple (Ananas comosus (L.) Merr.) from Tac Cau, Vietnam, represents a valuable source of bioactive compounds, particularly in its peel, a traditionally used ethnomedicinal material. This study evaluated the antioxidant and anti-melanogenesis activities of methanol and ethanol extracts from different pineapple parts (peel, leaf, flesh, and stem) and further characterised metabolites in the ethyl acetate peel fraction. Among all samples, the methanolic peel extract exhibited the highest phenolic and flavonoid contents and demonstrated the strongest radical scavenging, reducing power, and tyrosinase inhibitory effects, which correlated with significant suppression of melanin synthesis in B16F10 cells. The ethyl acetate fraction showed enhanced bioactivity, and LC-MS/MS analysis identified caffeic acid, p-coumaric acid, chlorogenic acid, and related phenylpropanoid derivatives as key constituents. These findings substantiate traditional uses of pineapple peel and highlight its potential for functional food and cosmeceutical development while promoting sustainable utilisation of local agro-resources.
Thi et al. (Fri,) studied this question.