In a family with familial hypercholesterolemia, the appearance and severity of cutaneous xanthomas were age-related, suggesting a role for the duration of hypercholesterolemia.
Case Report
Highlights the relationship between age (duration of hypercholesterolemia) and the severity of cutaneous xanthomas in familial hypercholesterolemia.
Familial homozygous hypercholesterolemia is a rare autosomal disorder characterized by high levels of cholesterol, extensive tendon xanthomatosis and premature development of atherosclerotic disease. Early coronary artery disease with myocardial infarctions and sudden deaths are common. We reported a family of familial hypercholesterolemia from the Kashmir valley of the Indian subcontinent. The appearance and the severity of the cutaneous xanthomas was found to be age related suggesting a role for the duration of hypercholesterolemia in the development of xanthomatosis.
Koul et al. (Sun,) conducted a case report in Familial hypercholesterolemia. In a family with familial hypercholesterolemia, the appearance and severity of cutaneous xanthomas were age-related, suggesting a role for the duration of hypercholesterolemia.