What question did this study set out to answer?

April 13, 2026Open Access

Efficacy and safety of e.p.t.q. hyaluronic acid fillers in the context of aesthetic facial rejuvenation or beautification: a post-market clinical follow-up study

Key Points

To evaluate the efficacy and safety of e.p.t.q. hyaluronic acid fillers in facial rejuvenation.
Conducted a post-market clinical follow-up study.
Evaluated WSRS, MFVDS, and MLFS scores at 4 weeks and 24 weeks.
Assessed the GAIS scores from both investigators and patients.
Monitored adverse events including serious adverse device effects.
WSRS, MFVDS, and MLFS scores peaked at 4 weeks, then declined by 24 weeks (p = 0.0000).
Significant changes in GAIS scores were observed at 24 weeks from 4 weeks (p = 0.0000).
A total of 88 AEs reported in 24 patients (10.39%; 95% CI 6.77–15.06).
No serious adverse events or device effects were reported.

Abstract

This study was conducted to assess the efficacy and safety of e.p.t.q. hyaluronic acid (HA) fillers (JETEMA Co., Ltd., Yongin, Korea) in the context of aesthetic facial rejuvenation or beautification. The patients were evaluated for changes in the Wrinkle Severity Rating Scale (WSRS) scores, the Mid-Face Volume Deficit Scale (MFVDS) scores and the Medicis Lip Fullness Scale (MLFS) scores at 24 weeks from baseline and those in the investigator- and patient-assessed Global Aesthetic Improvement Scale (GAIS) scores at 24 weeks from 4 weeks and rates of adverse events (AEs), serious AEs (SAEs) and serious adverse device effects (SADEs). The WSRS, MFVDS and MLFS scores reached the highest level at 4 weeks and showed declines thereafter until 24 weeks. Moreover, there were significant changes in the WSRS, MFVDS and MLFS scores at 24 weeks from baseline (p = 0.0000 for all). The investigator- and patient-assessed GAIS scores reached the highest level at 4 weeks and showed declines thereafter until 24 weeks. Moreover, there were significant changes in the investigator- and patient-assessed GAIS scores at 24 weeks from 4 weeks (p = 0.0000 for both). There were 88 cases of AEs in 24 patients (10.39%; 95% CI 6.77–15.06), three cases of ADEs in two (0.87%; 95% CI 0.11–3.09), no cases of SAEs, SADEs and unexpected SADEs in 0 (0.00%; 95% CI 0.00-1.58) and two cases of unexpected ADEs in one (0.43%; 95% CI 0.01–2.39). In conclusion, e.p.t.q. HA fillers might be considered for aesthetic facial rejuvenation or beautification.

KI fragen

Bookmark

View Full Paper