Are Pro-ANP plasma levels associated with anxiety in patients with severe heart failure?
High Pro-ANP levels are inversely associated with anxiety in severe heart failure, suggesting a potential negative feedback loop limiting psychological distress.
Pro-ANP plasma levels are independently and inversely related to anxiety. Even in severe CHF with severely compromised quality of life, anxiety tends to decrease with high pro-ANP levels. This might be part of a negative feedback loop limiting psychological distress and its adverse autonomic consequences in severe heart failure.
Herrmann‐Lingen et al. (Tue,) studied this question.