February 2, 2018Open Access

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

SLSreemathi LoganUniversity of Oklahoma Health Sciences Center GPGavin PharaohUniversity of Washington MMM. Caleb MarlinOklahoma Medical Research Foundation

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Abstract

Regulation of astrocytic mitochondrial function and redox status by IGF-1 is essential to maintain astrocytic function and coordinate hippocampal-dependent spatial learning. Age-related astrocytic dysfunction caused by diminished IGF-1 signaling may contribute to the pathogenesis of Alzheimer's disease and other age-associated cognitive pathologies.

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Logan et al. (Fri,) studied this question.

synapsesocial.com/papers/69dd2feb27c48be1bb40c52c https://doi.org/https://doi.org/10.1016/j.molmet.2018.01.013

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