November 1, 1999

Astrocytes in multiple sclerosis lack beta-2 adrenergic receptors

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Abstract

Because astrocytic beta2 adrenergic receptors are involved in suppressing inducibility of MHC class II molecules, we suggest that their lack of expression may play an important role in the induction or perpetuation of autoimmune reactions in MS.

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Keyser et al. (Mon,) studied this question.

synapsesocial.com/papers/69dd4ad87d97b7e86940c9d0 https://doi.org/https://doi.org/10.1212/wnl.53.8.1628

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4Norepinephrine inhibits gamma-interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms.1988 · 142 citations
5Persistent Paramyxovirus Infections and Behaviour of beta-Adrenergic Receptors in C-6 Rat Glioma Cells1980 · 37 citations