Do surface material and geometric configuration of endovascular stents dictate experimental restenosis and thrombosis?
Stent configuration and surface material are key determinants of neointimal hyperplasia and thrombosis in experimental models, suggesting future stent designs should optimize these factors.
Surface material and geometric configuration of stents may be more important than postplacement diameter in determining neointimal hyperplasia and thrombosis. Alterations in configuration affect vascular injury and neointimal hyperplasia, while surface material plays a greater role in thrombosis. Monocytes may be important modulators of stent-induced intimal thickening. Clinical confirmation of these findings may alter coronary stent deployment techniques and future stent designs.
Rogers et al. (Thu,) studied this question.