Do three major co-morbidities worsen quality of life and prognosis in stable advanced HFrEF patients?
In stable advanced HFrEF, major co-morbidities worsen prognosis but do not appear to impair quality of life.
In stable advanced HFrEF patients, co-morbidities are not associated with impaired QoL, but negatively affect the prognosis both directly and indirectly through lower level of HF pharmacotherapy and increased myocardial stress and injury.
Beneš et al. (Fri,) studied this question.