Hybrid benzylidene thiazolidine-2,4-diones as potent apoptosis-inducing anticancer agents: design-driven optimization, cytotoxic profiling, and mechanistic validation in prostate cancer

Key Points

• The research aims to explore the anticancer effects and mechanisms of hybrid benzylidene thiazolidine-2,4-diones in prostate cancer.
• Design-driven optimization of compound structure.
• Cytotoxic profiling to assess cell death efficacy.
• Mechanistic validation to understand apoptosis pathways.
• Hybrid compounds effectively induce apoptosis in prostate cancer cells.
• Significant cytotoxic effects observed compared to control.
• Mechanisms of action involve specific apoptotic pathways.