Does norepinephrine use increase the risk of acute kidney injury and in-ICU mortality in patients following cardiac surgery?
Norepinephrine use for vasoplegic syndrome following cardiac surgery is associated with increased risk of AKI and in-ICU mortality, suggesting caution in its use.
Norepinephrine was associated with AKI and in-ICU mortality following cardiac surgery. While these results discourage norepinephrine use for vasoplegic syndrome in cardiac surgery, prospective investigations are needed to substantiate findings and to suggest alternative strategies for organ protection.
Huette et al. (Sun,) studied this question.