Is increased serum resistin in NAFLD patients related to liver disease severity or insulin resistance?
Increased serum resistin in NAFLD patients correlates with the histological severity of liver disease rather than insulin resistance or BMI.
Both NAFLD and obese patients had lower adiponectin levels, whereas leptin was increased only in the obese group. No correlation was found between resistin and high-sensitivity C-reactive protein, BMI, homeostasis model assessment, insulin, glucose, transaminases, and lipid values. A positive correlation was found between resistin and histological inflammatory score. These data report increased resistin in NAFLD patients that is related to the histological severity of the disease, but do not support a link between resistin and insulin resistance or BMI in these patients.
Pagano et al. (Mon,) studied this question.
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