Does enoxaparin 40 mg once daily or 30 mg every 12 hours prevent deep venous thrombosis in patients having elective hip replacement surgery compared to 10 mg once daily?
Higher doses of enoxaparin (40 mg daily or 30 mg twice daily) are more effective than 10 mg daily for DVT prophylaxis after hip replacement surgery, with an acceptable risk of major hemorrhage.
After surgery, enoxaparin, 40 mg once daily or 30 mg every 12 hours, is more effective than a regimen of 10 mg once daily to prevent deep venous thrombosis in patients having elective hip replacement surgery. The regimens of 40 mg once daily and 30 mg every 12 hours provided prophylaxis similar to the most effective drug treatments previously reported. The incidence of hemorrhagic episodes with the regimens of 40 mg once daily and 30 mg twice daily was higher than that observed with 10 mg once daily; however, major hemorrhage occurred in only 4% to 5% of patients receiving the higher-dose regimens. The risk-to-benefit ratio supports the use of enoxaparin as a therapeutic agent to prevent deep venous thrombosis in these patients.
Spiro et al. (Fri,) studied this question.