Does chronic antioxidant therapy (tempol) lower blood pressure in Dahl salt hypertensive rats?
Chronic antioxidant therapy with tempol lowers blood pressure in adult Dahl salt hypertensive rats by attenuating sympathetic vasoconstriction.
Chronic antioxidant therapy lowered BP only in adult salt hypertensive Dahl-S rats in which superoxide levels were increased in both kidneys and aorta. Blood pressure reduction induced by chronic tempol treatment is related to attenuated sympathetic vasoconstriction rather than to augmented NO-dependent vasodilatation.
Vaněčková et al. (Tue,) studied this question.