What question did this study set out to answer?

This research aims to evaluate the relationship between the length of antibiotic therapy and 90-day mortality in mechanically ventilated sepsis patients with pneumonia.

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April 15, 2026Open Access

Short- versus long-course antibiotic therapy in mechanically ventilated sepsis patients with pneumonia: a real-world cohort analysis

Key Points

This research aims to evaluate the relationship between the length of antibiotic therapy and 90-day mortality in mechanically ventilated sepsis patients with pneumonia.
Conducted an observational cohort analysis
Compared short-course and long-course antibiotic therapies
Adjusted for potential confounding factors
Shorter antibiotic courses did not lead to increased 90-day mortality
Findings suggest potential signals that require further investigation
Data indicates the need for randomized trials for confirmation

Abstract

In this observational cohort, shorter antibiotic courses were not associated with increased 90‑day mortality after adjustment. Given potential confounding and limited recurrence data, subgroup signals are hypothesis‑generating and require confirmation in randomized trials.

Short- versus long-course antibiotic therapy in mechanically ventilated sepsis patients with pneumonia: a real-world cohort analysis

Key Points

Abstract

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