Role of Ca 2+ ‐Dependent Epithelial‐Mesenchymal Transition in Malignant Progression of Colorectal Cancer: Special Focus on REG Iα/ EDNRB

Key Points

• To explore how the REG Iα/EDNRB axis influences the malignant progression of colorectal cancer via Ca2+-dependent pathways.
• Analysis of REG Iα and EDNRB interactions
• Examination of epithelial-mesenchymal transition mechanisms
• Investigation of Ca2+ signaling roles in colorectal cancer progression
• Activation of Ca2+-dependent epithelial-mesenchymal transition indicates increased malignancy.
• REG Iα/EDNRB axis significantly contributes to colorectal cancer metastasis.
• Targeting this axis may offer new therapeutic strategies against colorectal cancer.