Does intraoperative dexmedetomidine infusion reduce anesthetic requirement and improve recovery from anesthesia compared to oral clonidine premedication in patients undergoing major spine surgery?
Intraoperative dexmedetomidine infusion provides a greater anesthetic-sparing effect than oral clonidine premedication in major spine surgery, with similar recovery and hemodynamic profiles.
Both clonidine and dexmedetomidine have anesthetic-sparing effect; however, it was more with dexmedetomidine than with clonidine. Recovery from isoflurane anesthesia was similar between both groups. Both are equally effective in controlling the hemodynamic response and reducing the blood loss during spine surgery.
Mariappan et al. (Thu,) studied this question.