Do specific metabolomic signatures in human calcified aortic valves correlate with the progression rate of calcific aortic valve stenosis?
Untargeted metabolomic analysis identified 72 altered metabolites across stages of calcific aortic valve stenosis, highlighting lysophosphatidic acid as a potential biomarker for faster hemodynamic progression.
This study outlines the first step toward creating the metabolite atlas of human calcified aortic valves by identifying the expression of metabolites and metabolic pathways involved at various stages of calcific aortic valve stenosis progression. Untargeted analysis identified 72 metabolites and lipids that were significantly altered (p < 0.01) across different stages of disease progression. Of these metabolites and lipids, the levels of lysophosphatidic acid were shown to correlate with faster hemodynamic progression and could select patients at risk for faster progression rate.
Surendran et al. (Tue,) studied this question.